§ Federal grant opportunity · RFA-HG-27-009
Genomic Variant Interactions With Other Variants Or The Environment (UM1 Clinical Trials Not Allowed)
National Institutes of Health is accepting applications for Genomic Variant Interactions With Other Variants Or The Environment (UM1 Clinical Trials Not Allowed). The deadline is December 14, 2026 and the published award range is $1.5M.
Key facts
- Funder
- National Institutes of Health
- Application deadline
- December 14, 2026
- Award range
- $1.5M
- Eligibility
- nonprofits non higher education without 501c3, state governments, independent school districts, county governments, nonprofits non higher education with 501c3, federally recognized native american tribal governments, small businesses, private institutions of higher education, for profit organizations other than small businesses, public and indian housing authorities, city or township governments, special district governments, other native american tribal organizations, public and state institutions of higher education, other
- Geography
- United States
- Focus areas
- Health
- Opportunity number
- RFA-HG-27-009
Program overview
The purpose of this Notice of Funding Opportunity (NOFO) is to solicit applications to study the effects of genetic or environmental interactions on genomic variant impact. To accomplish this, interaction centers will first propose a research framework to investigate whether interactions with effects beyond additive are important modifiers of the impact of variants. Centers will apply their framework to experimentally test combinations for interactions and share their data as well as analyses through the Impact of Genomic Variation on Function (IGVF) portal and catalog. Centers will share their method for predicting the most important combinations for future testing. The rationale for this combination of research and resource work is the identification of a structure within the interaction landscape might result in better predictions of the most important interactions to test, leading to more effective variant testing, better understanding of genome-wide association studies (GWAS), and improved polygenic scores. As IGVF Consortium members, centers will work together to ensure all consortium resources are accessible to a wide variety of potential users. Centers are also expected to collaborate with other consortium components to coordinate assays, variants, and cell types, and to develop shared analysis strategies to meet consortium goals.
How to apply
- Confirm your organization meets the eligibility criteria above.
- Read the full funding opportunity announcement from National Institutes of Health.
- Draft your narrative against the funder's stated priorities and review criteria.
- Submit before December 14, 2026, allowing time for registration and validation.
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