§ Federal grant opportunity · RFA-HG-27-007
Systematic Characterization of Genomic Variation to Assess Effects of Individual Variants on Genome Function and Phenotype (UM1 Clinical Trials Not Allowed)
National Institutes of Health is accepting applications for Systematic Characterization of Genomic Variation to Assess Effects of Individual Variants on Genome Function and Phenotype (UM1 Clinical Trials Not Allowed). The deadline is December 14, 2026 and the published award range is $2M.
Key facts
- Funder
- National Institutes of Health
- Application deadline
- December 14, 2026
- Award range
- $2M
- Eligibility
- public and state institutions of higher education, nonprofits non higher education without 501c3, private institutions of higher education, other native american tribal organizations, small businesses, state governments, nonprofits non higher education with 501c3, for profit organizations other than small businesses, public and indian housing authorities, independent school districts, other, county governments, city or township governments, federally recognized native american tribal governments, special district governments
- Geography
- United States
- Focus areas
- Health
- Opportunity number
- RFA-HG-27-007
Program overview
The purpose of this Notice of Funding Opportunity (NOFO) is to solicit applications to characterize genomic variation to assess the impact of individual variants on genome function. This will be accomplished by systematically perturbing variants or elements using one or more high-throughput methods; collecting data on the effects of variants in DNA, RNA, or protein-coding elements on molecular, cellular, or organismal phenotypes; and developing robust, reproducible, and portable data processing pipelines. Centers funded through this initiative will become a part of the Impact of Genomic Variation on Function (IGVF) Consortium. As consortium members, centers will work together to ensure all consortium resources are accessible to a wide variety of potential users. Centers are also expected to collaborate with other consortium components to coordinate assays, variants, and cell types, and to develop shared analysis strategies to meet consortium goals.
How to apply
- Confirm your organization meets the eligibility criteria above.
- Read the full funding opportunity announcement from National Institutes of Health.
- Draft your narrative against the funder's stated priorities and review criteria.
- Submit before December 14, 2026, allowing time for registration and validation.
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