§ Federal grant opportunity · DE-FOA-0003612
The Genesis Mission: Transforming Science and Energy with AI
Michael S Zarkin Grants Management Specialist is accepting applications for The Genesis Mission: Transforming Science and Energy with AI. The deadline is December 17, 2026 and the published award range is $500K – $16M.
Key facts
- Funder
- Michael S Zarkin Grants Management Specialist
- Application deadline
- December 17, 2026
- Award range
- $500K – $16M
- Eligibility
- Eligibility criteria are published in the funding opportunity announcement.
- Geography
- United States
- Focus areas
- Research
- Opportunity number
- DE-FOA-0003612
Program overview
The DOE Office of Science (SC), Office of Critical Minerals and Energy Innovation (CMEI), Office of Environmental Management (EM), Office of Nuclear Energy (NE), Office of Electricity (OE), and Hydrocarbons and Geothermal Office (HGEO) hereby announce interest in receiving applications from interdisciplinary teams addressing the Genesis Mission National Science and Technology Challenges to accelerate scientific discovery and research and development (R&D) workflows using novel artificial intelligence (AI) models and frameworks. By achieving AI advantage, these teams will advance the DOE's mission and ensure America’s security and prosperity by addressing energy, environmental, and nuclear challenges through science and technology. Teams are encouraged to leverage the extensive scientific and data resources of the DOE/National Nuclear Security Administration (NNSA), the National Laboratories, U.S. industry, and academia. The resulting AI models and workflows, if successful, may be integrated into the American Science Cloud. DOE is soliciting new FY26 Phase I small team and Phase II large team applications in the following topic areas: advanced manufacturing, biotechnology, critical materials, nuclear fission, nuclear fusion, quantum information science, semiconductors and microelectronics, discovery science, and energy (see specific focus areas in Section III Program Descriptions). In addition, this RFA will remain available to allow the recipients of FY26 Phase I awards to apply for larger team Phase II awards. In a few weeks, DOE plans to amend the RFA to clarify the LOI and application guidelines for FY26 Phase II awards. In FY27, DOE plans to amend the RFA or to issue an alternative funding opportunity to update the topic and focus areas to allow a second competition of Phase I small team applications and Phase II large team applications.
How to apply
- Confirm your organization meets the eligibility criteria above.
- Read the full funding opportunity announcement from Michael S Zarkin Grants Management Specialist.
- Draft your narrative against the funder's stated priorities and review criteria.
- Submit before December 17, 2026, allowing time for registration and validation.
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